(CNN) Updated at 4:34 p.m. ET: Former Democratic presidential candidate George McGovern was on life support and "no longer responsive" on Wednesday, two days after he was admitted to a hospice, his family said.
The 90-year-old former U.S. senator from South Dakota was admitted to hospice in Sioux Falls on Monday "with a combination of medical conditions, due to age, that have worsened over recent months," according to a statement from his family.
McGovern is known in part for his unsuccessful 1972 campaign for president as the Democratic nominee against incumbent Republican Richard Nixon.
In 1972, McGovern was selected as the Democratic Party nominee for president on a platform that included ending the war in Vietnam at a time when the country was torn over U.S. involvement there. The McGovern ticket earned only 17 electoral votes – from Massachusetts and the District of Columbia – to Nixon's 520.
McGovern represented South Dakota in the U.S. Senate and House before and after his presidential campaign, leaving the daily foray of politics after losing his 1980 bid for a fourth Senate term.
McGovern has remained active since, including an appointment by then-President Bill Clinton as an ambassador to the U.N. Food and Agriculture Organization and a 2001 appointment as the U.N.'s first global ambassador for hunger.
Sen. George McGovern ran for president in 1972 against incumbent Republican Richard Nixon.
